Skin Care Ingredients: Peptides 


All matter begins with electrons and protons, the building components of the elements. Proteins start with amino acids. There are 20 essential ones, and a few others, that make up life’s proteins. When two amino acids are combined, a new chemical called a peptide is formed. Circadia uses four different families of peptides to enhance skin health.



Preventhilia™ (Diaminopropionoyl Tripeptide-33) – Tetrapeptide that prevents the damage caused directly or indirectly by UV radiation to DNA and proteins, thus preventing photo-aging


Matrixyl™ (Palmitoyl Pentapeptide-4) – Helps stimulate collagen synthesis and elastin. The action is very similar to retinol without the irritation.

Matrixyl™ 3000 (Palmitoyl Oligopeptide and Palmitoyl Tetrapeptide-7) – Helps repair damaged tissues

Matrixyl™ Synthe 6 (Palmitoyl Tripeptide-38) – Evens out skin, relieves and smoothes wrinkles by stimulating constituents of skin matrix and dermal-epidermal junction (i.e. collagen I, II, IV, fibronectin, hyaluronic acid, and laminin 5)

Eyeliss™ (Hesperidin Methyl Chalcone and Dipeptide-2 and Palmitoyl Tetrapeptide-7) – Hesperidin methyl chalcone is a bioflavonoid that helps to decrease capillary permeability thus reducing fluid deposition and puffiness. Dipeptide Valyl-Tryptophane improves lymphatic circulation to promote drainage of under-eye fluid. Lipopeptide Pal-GQPR improves firmness and elasticity

Haloxyl® (Palmitoyl Oligopeptide and Palmitoyl Tetrapeptide-7) – Two peptides work in conjunction to improve firmness and tone of the eye area. Chrysin and N-hydroxysuccinimide stimulate the clearance of deposited blood pigments and solubilize iron for elimination respectively, resulting in the reduction of dark circles

Argireline® (Acetyl Hexapeptide-8) – A peptide alternative to botox that attenuates muscle contraction preventing the formation of fine lines and wrinkles

Snap 8 (Acetyl Octapeptide-3) – Reduces depth of wrinkles caused by contraction of muscles of facial expression

Inyline® (Acetyl Hexapeptide-30) – Reduces depth of wrinkles caused by contraction of muscles of facial expression

dGlyage® (Tripeptide 9) – Reduces DNA damage resulting from fenton reaction products and reduces metal-mediated A.G.E. formation

Vilastene™ (Tripeptide-10) – Inhibits mallard reaction and reduces A.G.E.s

Progeline™ (Trifluoroacetyl Tripeptide-2) – Reduces progerin synthesis, MMP and elastase inhibitor, increases syndecan, contracts collagen to reduce signs of aging including sagging and wrinkles

Thymulen® 4 (Acetyl Tetrapeptide-2) – Biomimetic of thymopoietin; boosts skin regeneration and reinforces cutaneous immune defenses

Chronocyclin® (Glutamylamidoethyl Imidazole) – Anti-aging, enhances expression of circadian genes, optimizes cell defenses and renewal activities, and Vitamin D transformation

L-Carnosine – Di-peptide that has anti-glycation properties

Ronacare® Cyclopeptide-5 – A novel cyclopeptide binds integrins and increases signaling for extracellular matrix production and crosstalk between skin cells. This results in increased tensil and compressive strength, elasticity, and firmness for the skin. Additionally, wrinkles are reduced and the skin is smoothed and crosstalk between skin cells. This results in increased tensil and compressive strength, elasticity, and firmness for the skin. Additionally, wrinkles are reduced and the skin is smoothed


Diffuporine™ (Acetyl Hexapeptide-37) – Boosts Aquaporin-3 which promotes inner hydration mechanisms and water movement from the basal layer of epidermis and to the stratum corneum, rejuvenating the skin by improving barrier function, collagen I synthesis and cellular proliferation


Telangyn™ (AcetylTripeptide-33) – Decreases facial redness and other skin disorders caused by the release of interleukins, reducing redness, dilated blood vessels, tissue degradation and post-inflammatory

Delisens™ (Acetyl Hexapeptide-46) – Down regulates PAR-2 thus reducing discomfort of pain and itching occurring in sensitive skin and restoring damaged barrier integrity, also increasing hydration, improves scaling, smoothing and softness in very dry skin

Thermostressine™ (Acetyl Tetrapeptide-22) – Helps fight cellular stress and increases HSP70 levels to prevent further stress


Melanostatin® 5 (Nonapeptide-1) – Skin whitening peptide antagonist alpha-melanocyte stimulating hormone (α-MSH) blocking tyrosinase activation

B-White™ (Oligopeptide-68) – Reduces MITF (microphthalmia-associated transcription factor) to decrease constitutive and facultative pigmentation pathways. Decreases tyrosinase activity and melanin synthesis to reduce overall skin pigmentation


Bodyfensine® (Acetyl Dipeptide-3) – Human β-defensin-2 and -3 mimetics that reinforce skin’s natural immunity and lower risk of possible infections from external agents

GranActive™ Acne (Oligopeptide -10) – a patented anti-microbial peptide from plant amino acid that promotes healthy skin tone


Liporeductyl® (Tripeptide-1) – Activates lipolysis and microcirculation

Silusyne™ (Acetyl Hexapeptide-39) – Reduces adipogenesis (new fat) by decreasing PGC-1α activity


L-Alanine – Skin conditioning agent and an essential amino acid in the conversion of proteins into energy, through the glucose metabolic pathway.

L-Glycine – Building block of collagen formation and the most plentiful amino acid in the body. While not an essential amino acid, since the body is able to synthesize it, it is a critical component in the synthesis of purines, an essential component of DNA.

L-Lysine – Heals while it soothes inflamed areas. L-Lysine is a necessary amino acid for all protein sin the body. L-Lysine is critical for calcium absorption, as a muscle protein, essential in recovering from  surgery, and in the body’s production of hormones, enzymes, and antibodies.

L-Proline – Essential amino acid that is required to make collagen fibers. It is the precursor of hydroxy proline and essential component of collagen cross-linking. It aids in wound healing, and in maintaining a youthful appearance of skin.

L-Threonine – Anti-oxidant stabilizer and an essential amino acid in building proteins. Threonine can be converted to pyruvate and use in the Krebs cycle, but it’s more common role is in building proteins and acting as a antioxidant stabilizer. The body cannot synthesize it is essential amino acid.

L-Valine – Reduces inflammation, but is an essential amino acid for building proteins. It is one of the three branched chain amino acids and is hydrophobic. It is widely used by muscle builders to increase muscle mass.